Molecular pathology parameters in human nasopharyngeal carcinoma
نویسندگان
چکیده
منابع مشابه
Molecular pathology of gastric carcinoma.
Gastric carcinoma (GC) is a biologically heterogeneous disease involving numerous genetic and epigenetic alterations. A very small proportion of GCs can be caused by a specific germ-line mutation of the E-cadherin gene (CDH1). Sporadic GC is developed through multistep processes that begin with Helicobacter pylori-induced atrophic gastritis. Epstein-Barr virus is another infectious cause of GC,...
متن کاملNasopharyngeal carcinoma in situ in nasopharyngeal carcinoma.
AIMS To assess the presence of carcinoma in situ (CIS) in patients with nasopharyngeal carcinoma (NPC) and to see if the number of biopsy sites facilitates detection of CIS. METHODS Formalin fixed, paraffin wax embedded biopsy specimens (n = 285) from 187 patients with NPC in 1987 were studied for the presence of CIS as well as for the histological assessment of the subtype of CIS. RESULTS ...
متن کاملHigh-risk human papillomavirus in nasopharyngeal carcinoma.
BACKGROUND Human papillomavirus (HPV), a cause of oropharyngeal carcinoma, has also been implicated as an etiologic agent in nasopharyngeal carcinomas. METHODS We performed p16 immunohistochemistry and in situ hybridization for Epstein-Barr virus (EBV) and HPV on 45 carcinomas of the nasopharynx. RESULTS Thirty-four (76%) carcinomas were EBV-positive/HPV-negative, 7 (16%) were EBV-negative/...
متن کاملHuman papilloma virus and nasopharyngeal carcinoma: pathology, prognosis, recurrence and mortality of the disease.
BACKGROUND One of the malignant tumors among head and neck cancers is nasopharyngeal carcinoma. Many studies consider human papilloma virus (HPV) as a cause for nasopharyngeal carcinoma. METHODS 41 paraffin-wax-embedded block samples were examined to detect HPV DNA and its subtype's presence by polymerase chain reaction. The recurrence, prognosis and survival were evaluated for an average of ...
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Four different genetic abnormalities may occur in endometrioid adenocarcinomas of the endometrium (mircosatellite instability and mutations in the PTEN, k-RAS and beta-catenin genes), whereas nonendometrioid carcinomas of the endometrium often have p53 mutations and loss of heterozygosity on several chromosomes. Occasionally, a nonendometrioid carcinoma may develop as a result of dedifferentiat...
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ژورنال
عنوان ژورنال: Cancer
سال: 2002
ISSN: 0008-543X
DOI: 10.1002/cncr.0679